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Finasteride acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Finasteride acetate图片
CAS NO:222989-99-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
醋酸非那雄胺
MK-906 acetate
产品介绍
Finasteride (MK-906) acetate 是一种有效的竞争性 5α-还原酶 (5α-reductase) 抑制剂,对 II 型 5α-还原酶的IC50值为 4.2 nM。Finasteride acetate 对 II 型 5α-还原酶的亲和力比对 I 型酶高约 100 倍。Finasteride acetate 可用于研究前列腺增生 (BPH) 和雄激素性脱发。
生物活性

Finasteride (MK-906) acetate is a potent and competitive5α-reductaseinhibitor, with anIC50of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

IC50& Target

IC50: 4.2 nM (type II 5α-reductase)[1]

体外研究
(In Vitro)

Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells[2].
Finasteride decreases the conversion of [3H]testosterone (T) to [3H]dihydrotestosterone (DHT) inP. crustosum[1].

Cell Viability Assay[2]

Cell Line:PC-3, DU-145, and LNCaP cells
Concentration:10 μM
Incubation Time:6, 12, 24 h
Result:Increased the expression of HO-1 protein in a time-dependent manner in PC-3 cells.
Induced the expression of Nrf2 protein in DU-145 and PC-3 cells, but not in LNCaP cells.
体内研究
(In Vivo)

Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration[3].

Animal Model:Male dogs with spontaneous BPH (2.7-11 years old; 10.3-49 kg)[3]
Dosage:0.1-0.5 mg/kg
Administration:P.o. once daily for 16 weeks
Result:Decreased prostatic diameter (20%), prostatic volume (43%), and serum DHT concentration (58%).
Decreased semen volume but did not adversely effect on semen quality or serum testosterone concentration.
No adverse effects on dogs.
Clinical Trial
分子量

432.60

Formula

C25H40N2O4

CAS 号

222989-99-3

中文名称

醋酸非那雄胺;醋酸非那斯特萊

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.