CAS NO: | 146117-78-4 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | LY191704, as a benzoquinolinone, is a potent, nonsteroidal, noncompetitive and selectivehuman type I 5α-reductaseinhibitor. LY191704 is a racemic mixture of the compounds LY300502 and LY300503. LY191704 may be useful in the research of human endocrine disorders associated with overproduction of dihydrotestosterone (DHT) by5α-reductase type 1[1][2]. | ||||||||
IC50& Target | Human Type I 5α-Reductase[1][2] | ||||||||
体外研究 (In Vitro) | LY191704 (0.001-100 uM) inhibits the conversion of testosterone to DHT with an IC50of 10 nM in Hs68 cells. LY191704 inhibits the enzyme expressed by the human cells with an IC50of 12 nM but is virtually inactive against the 5α-reductase expressed by rat prostate cells. LY191704 is a potent and specific inhibitor of human 5α-reductase type 1 but had little or no activity against human 5α-reductase type 2 or rat 5α-reductase type 1. A Kivalue of 17.1 μM is determined for the human type 2 enzyme, indicating that LY191704 demonstrates an 5000-fold selectivity for the human type 1 isozyme[2]. | ||||||||
体内研究 (In Vivo) | LY191704 (10, 30, or 100 mg/kg; p.o.; 1 month) increases plasma concentrations[1].
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分子量 | 249.74 | ||||||||
Formula | C14H16ClNO | ||||||||
CAS 号 | 146117-78-4 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |