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LY191704
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY191704图片
CAS NO:146117-78-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
LY191704 作为一种苯并喹啉酮,是一种高效、非甾体、非竞争性和选择性human type I 5α-reductase抑制剂。LY191704 是 LY300502 和 LY300503 化合物的外消旋混合物。LY191704 可能有助于研究由human type I 5α-reductase产生的二氢睾酮 (DHT) 过多引起的人类内分泌紊乱。
生物活性

LY191704, as a benzoquinolinone, is a potent, nonsteroidal, noncompetitive and selectivehuman type I 5α-reductaseinhibitor. LY191704 is a racemic mixture of the compounds LY300502 and LY300503. LY191704 may be useful in the research of human endocrine disorders associated with overproduction of dihydrotestosterone (DHT) by5α-reductase type 1[1][2].

IC50& Target

Human Type I 5α-Reductase[1][2]

体外研究
(In Vitro)

LY191704 (0.001-100 uM) inhibits the conversion of testosterone to DHT with an IC50of 10 nM in Hs68 cells. LY191704 inhibits the enzyme expressed by the human cells with an IC50of 12 nM but is virtually inactive against the 5α-reductase expressed by rat prostate cells. LY191704 is a potent and specific inhibitor of human 5α-reductase type 1 but had little or no activity against human 5α-reductase type 2 or rat 5α-reductase type 1. A Kivalue of 17.1 μM is determined for the human type 2 enzyme, indicating that LY191704 demonstrates an 5000-fold selectivity for the human type 1 isozyme[2].

体内研究
(In Vivo)

LY191704 (10, 30, or 100 mg/kg; p.o.; 1 month) increases plasma concentrations[1].

Animal Model:Rats[1]
Dosage:10, 30, or 100 mg/kg
Administration:P.o.; 1 month
Result:Increased plasma concentrations.
分子量

249.74

Formula

C14H16ClNO

CAS 号

146117-78-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.