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Alpha-Estradiol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alpha-Estradiol图片
CAS NO:57-91-0
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
100mg电议
500mg电议
1 g电议
5 g电议

产品名称
α-雌二醇
Alfatradiol
Epiestradiol
Epiestrol
产品介绍
Alpha-Estradiol 是一种雌性激素,是5α-reductase抑制剂,有潜力用于雄原性脱发的研究。
生物活性

Alpha-Estradiol is a weak estrogen and a5α-reductaseinhibitor which is used as a topical medication in the treatment of androgenic alopecia.

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase[1]. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression[2].

体内研究
(In Vivo)

Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17[3].

分子量

272.38

性状

Solid

Formula

C18H24O2

CAS 号

57-91-0

中文名称

雌二醇EP杂质L (17-epi-Estradiol)

结构分类
  • Phenols
  • Monophenols
  • Steroids
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 62.5 mg/mL(229.46 mM;ultrasonic and warming and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.6713 mL18.3567 mL36.7134 mL
5 mM0.7343 mL3.6713 mL7.3427 mL
10 mM0.3671 mL1.8357 mL3.6713 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。