Emodin-d4 (Frangula emodin-d4) is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoVcompound. Emodin blocks the SARS coronavirus spike protein andangiotensin-converting enzyme 2 (ACE2)interaction^[1]. Emodin inhibitscasein kinase-2(CK2). Anti-inflammatory and anticancer effects^[2]. Emodin is a potent selective11β-HSD1inhibitor with theIC₅₀of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

274.26

C₁₅H₆D₄O₅

132796-52-2

大黄素 d4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.