CAS NO: | 1204329-34-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | BI-9627 is potent sodium-hydrogen exchanger isoform 1(NHE1)inhibitor, withIC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 shows low DDI (drug-drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury[1]. | ||||||||||||||||
IC50& Target | IC50: 6 nM (NHE1 in intracellular pH recovery assay), 31 nM (NHE1 in human platelet swelling assay)[1] | ||||||||||||||||
分子量 | 356.34 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C16H19F3N4O2 | ||||||||||||||||
CAS 号 | 1204329-34-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(280.63 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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