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Tenapanor hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tenapanor hydrochloride图片
CAS NO:1234365-97-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
AZD1722 hydrochloride
RDX5791 hydrochloride
产品介绍
Tenapanor (AZD1722) hydrochloride 是一种有效且具有口服活性的钠/氢交换异构体 3 (NHE3) (sodium/hydrogen exchanger isoform 3 (NHE3)) 抑制剂。Tenapanor hydrochloride 主要通过减少被动细胞旁磷酸盐通量来减少肠道对磷酸盐的吸收。Tenapanor hydrochloride 具有研究高磷血症的潜力。
生物活性

Tenapanor (AZD1722) hydrochloride is a potent and orally activesodium/hydrogen exchanger isoform 3 (NHE3)inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia[1][2].

体内研究
(In Vivo)

Tenapanor hydrochloride (0.15, 0.5 mg/kg; p.o.) reduces passive paracellular phosphate absorption in rats[1].
Tenapanor hydrochloride (0.15 mg/kg; p.o.; twice-daily for 11 consecutive days) increases the reduction in urinary phosphorus excretion in rats[2].

Animal Model:Rats (intestinal loop model)[1]
Dosage:0.15, 0.5 mg/kg
Administration:P.o.
Result:Reduced passive paracellular phosphate absorption by reduced urinary phosphate and sodium excretion after the high-phosphate meal and increased sodium and phosphate delivery to the cecum.
Animal Model:8 weeks, 250 g male Sprague–Dawley rats[2]
Dosage:0.15 mg/kg in combination with sevelamer (0%, 0.75%, 1.5%, and 3% (wt/wt))
Administration:Oral gavage; twice-daily for 11 consecutive days
Result:Significantly augmented the reduction in urinary phosphorus excretion.
Clinical Trial
分子量

1217.97

Formula

C50H68Cl6N8O10S2

CAS 号

1234365-97-9

中文名称

盐酸替那帕诺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.