CAS NO: | 2898-76-2 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Benzamil (Benzylamiloride), an Amiloride analogue, is aNa+/Ca2+exchanger (NCX)inhibitor (IC50~100 nM). Benzamil also is a non-selectiveDeg/epithelial sodium channels (ENaC)blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50of 1.1 μM[1][2][3]. |
体外研究 (In Vitro) | Benzamil (Benzylamiloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+channels[4]. |
体内研究 (In Vivo) | Benzamil (Benzylamiloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats[5]. |
分子量 | 319.75 |
Formula | C13H14ClN7O |
CAS 号 | 2898-76-2 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |