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Benzamil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Benzamil图片
CAS NO:2898-76-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Benzylamiloride
产品介绍
Benzamil (Benzylamiloride),是 Amiloride 类似物,是一种 Na+/Ca2+交换体(NCX)抑制剂,(IC50~100 nM)。Benzamil 也是一种非选择性Deg/epithelial sodium channels (ENaC)阻滞剂,能增强肌源性血管收缩。Benzamil 抑制 TRPP3 介导的 Ca2+激活电流,IC50为 1.1 μM。
生物活性

Benzamil (Benzylamiloride), an Amiloride analogue, is aNa+/Ca2+exchanger (NCX)inhibitor (IC50~100 nM). Benzamil also is a non-selectiveDeg/epithelial sodium channels (ENaC)blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50of 1.1 μM[1][2][3].

体外研究
(In Vitro)

Benzamil (Benzylamiloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+channels[4].

体内研究
(In Vivo)

Benzamil (Benzylamiloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats[5].

分子量

319.75

Formula

C13H14ClN7O

CAS 号

2898-76-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.