PPADS tetrasodium

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PPADS tetrasodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

192575-19-2

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
1mg	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

PPADS tetrasodiuma 是一种非选择性P2X受体拮抗剂。PPADS tetrasodiuma 阻断重组P2X1、-2、-3、-5，IC₅₀范围为1～2.6 μM。PPADS-tetrasodiuma 阻断天然 P2Y2 样 (IC₅₀~0.9 mM) 和重组 P2Y4 (IC₅₀~15 mM) 受体。PPADS tetrasodiuma 是豚鼠气道平滑肌 Na/Ca2+ 交换逆模式的抑制剂。

生物活性

PPADS tetrasodiuma is a non-selectiveP2X receptorantagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 withIC₅₀s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC₅₀~0.9 mM) and recombinant P2Y4 (IC₅₀~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca²⁺exchanger in guinea pig airway smooth muscle^[1]^[2].

体外研究
(In Vitro)

PPADS tetrasodiuma (1-30 μM; 10-50 minutes) inhibits Na+/Ca2+ exchanger reverse mode (NCXREV) in a time- and concentration dependent manner^[2].
PPADS tetrasodiuma is effective at other native and recombinant P2XRs. At human P2XRs sensitivity to PPADS tetrasodiuma depended on the subtype and is highest at the hP2X1, -2, -3, -5, and -7Rs with an IC₅₀of ~1-3 and ~30 μM for the hP2X4R^[3].

体内研究
(In Vivo)

PPADS tetrasodiuma (15-60 mg/100g body weight (BW); i.p.; every 12 hours for 8 days) inhibits glomerular mesangial cells (MC) proliferation without altering proliferation of non-MC in vivo in mesangial proliferative glomerulonephritis^[4].

Animal Model:	Male Sprague-Dawley ratsweighing 160 to 200 g (anti-Thy1 disease mode)^[4]
Dosage:	15 mg/100g BW, 30 mg/100g BW, 60 mg/100g BW
Administration:	i.p.; every 12 hours for 8 days (the first PPADS injection was administered 60 minutes after disease induction, and the loading dose always contained double the amount of PPADS compared to the following injections.)
Result:	Specifically and dose-dependently reduced early (day 3) glomerular mesangial cell proliferation without altering proliferation of non-MC.

分子量

599.30

性状

Solid

Formula

C₁₄H₁₀N₃Na₄O₁₂PS₂

CAS 号

192575-19-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 50 mg/mL(83.43 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.6686 mL	8.3431 mL	16.6861 mL
5 mM	0.3337 mL	1.6686 mL	3.3372 mL
10 mM	0.1669 mL	0.8343 mL	1.6686 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。