CAS NO: | 837424-39-2 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | YM-244769 hydrochloride is a potent, selective and orally active Na+/Ca2+exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+entry mode), withIC50s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice[1][2][3]. | ||||||||||||
IC50& Target | IC50: 18 nM (NCX3)[1] | ||||||||||||
体外研究 (In Vitro) | YM-244769 (0.003-1 μM) inhibits dose dependently the initial rates of45Ca2+uptake into NCX1, NCX2, and NCX3 transfectants with IC50values of 68 ± 2.9, 96 ± 3.5, and 18 ± 1.0 nM, respectively[1]. | ||||||||||||
体内研究 (In Vivo) | YM-244769 (0.1-1 mg/kg; p.o.; once) exhibits dose-dependently natriuretic action in mice and significantly increased urinary excretion of Ca2+as well as Ca2+/Cr ratio[2].
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分子量 | 479.93 | ||||||||||||
性状 | Solid | ||||||||||||
Formula | C26H23ClFN3O3 | ||||||||||||
CAS 号 | 837424-39-2 | ||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
储存方式 |
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