CAS NO: | 2250019-94-2 |
包装: | 1mg |
生物活性 | AR-C141990 hydrochloride is a potentlactate transporters (monocarboxylate transporters; MCTs)inhibitor withpKivalues of 7.6, 6.6 for MCT-1 and MCT-2, respectively[1]. AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response[2]. |
IC50& Target | pKi: 7.6 (MCT-1) and 6.6 (MCT-2)[1] |
体外研究 (In Vitro) | AR-C141990 hydrochloride has no significant activity against MCT-3 (pIC50<5) or MCT-4 (pIC50<5)[1]. |
体内研究 (In Vivo) | AR-C141990 hydrochloride (10 mg/kg; SC) with a parallel decline in plasma concentrations with a half-life around 20 minutes in male NMRI mice (18-22 g)[2]. |
分子量 | 529.05 |
Formula | C26H29ClN4O4S |
CAS 号 | 2250019-94-2 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |