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AR-C141990 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AR-C141990 hydrochloride图片
CAS NO:2250019-94-2
包装:1mg

产品介绍
AR-C141990 hydrochloride 是一种有效的乳酸转运蛋白 (monocarboxylate transporters; MCTs) 抑制剂,对 MCT-1 和 MCT-2 的pKi分别为 7.6、6.6。AR-C141990 hydrochloride 具有免疫抑制特性,可抑制移植物抗宿主反应。
生物活性

AR-C141990 hydrochloride is a potentlactate transporters (monocarboxylate transporters; MCTs)inhibitor withpKivalues of 7.6, 6.6 for MCT-1 and MCT-2, respectively[1]. AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response[2].

IC50& Target

pKi: 7.6 (MCT-1) and 6.6 (MCT-2)[1]

体外研究
(In Vitro)

AR-C141990 hydrochloride has no significant activity against MCT-3 (pIC50<5) or MCT-4 (pIC50<5)[1].
AR-C141990 hydrochloride inhibits the uptake of [3H]HOCPCA in oocytes expressing MCT1 or 2 in a concentration-dependent manner with IC50s of 0.21 μM and 2.32 μM, respectively[2].

体内研究
(In Vivo)

AR-C141990 hydrochloride (10 mg/kg; SC) with a parallel decline in plasma concentrations with a half-life around 20 minutes in male NMRI mice (18-22 g)[2].
Application of the corresponding plasma concentrations of AR-C141990 hydrochloride (0.3-90 mg/kg) results in a concentration-dependent decrease in the B/P of HOCPCA with an EC50of 860 ng/ml[2].
AR-C141990 (100 mg/kg; s.c.) has a moderate prolongation of graft survival for 40 days in PVG rats that received DA cardiac transplants[1].

分子量

529.05

Formula

C26H29ClN4O4S

CAS 号

2250019-94-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.