CAS NO: | 50995-74-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
生物活性 | 7ACC1(DEAC; Coumarin D 1421; D 1421) selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressingMCT1andMCT4transporters. IC50 value: 0.86 uM(Lactate uptake inhibition) [1] Target: MCT inhibitor; lactate transport inhibitor Contrary to the referenceMCT1 inhibitorAR-C155858, 7ACC unexpectedly inhibited lactate influx but not efflux in tumor cells expressingMCT1andMCT4transporters. 7ACC delayed the growth of cervix SiHa tumors, colorectal HCT116 tumors, and orthoptopic MCF-7 breast tumors. MCT target engagement was confirmed by the lack of activity of 7ACC on bladder UM-UC-3 carcinoma that does not express functional MCT. 7ACC also inhibited SiHa tumor relapse after treatment with cisplatin. Finally, we found that contrary to AR-C155858, 7ACC did not prevent the cell entry of the substrate-mimetic drug 3-bromopyruvate (3BP) throughMCT1, and contributed to the inhibition of tumor relapse after 3BP treatment. | ||||||||||||||||
分子量 | 261.27 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C14H15NO4 | ||||||||||||||||
CAS 号 | 50995-74-9 | ||||||||||||||||
Excitation (Ex) | Ex 380-450 nm Violet | ||||||||||||||||
中文名称 | 香豆素D1421 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 33.33 mg/mL(127.57 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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