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MCT1-IN-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MCT1-IN-3图片
CAS NO:2878360-80-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
MCT1-IN-3 是一种单羧酸转运蛋白 1(MCT1)抑制剂,IC50值为 81.0 nM。MCT1-IN-3 还对多药转运蛋白ABCB1具有显著的抑制作用。MCT1-IN-3 可用于癌症的研究。
生物活性

MCT1-IN-3 is amonocarboxylate transporter1 (MCT1)inhibitor with anIC50value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporterABCB1. MCT1-IN-3 can be used for the research ofcancer[1].

IC50& Target

IC50: 81.0 nM (MCT1)[1]
GI50: 20 μM (A-549); 15.1 μM (MCF-7)[1]

体外研究
(In Vitro)

MCT1-IN-3 (compound 24) 对 MCT1 具有抑制活性,IC50值为 81.0 nM[1]
MCT1-IN-3 对表达 MCT1 的癌细胞系 A-549 和 MCF-7 具有很强的抗增殖活性,GI50值分别为 20 μM 和 15.1 μM[1]< /sup>.
MCT1-IN-3(5 μM;24 h)导致癌细胞周期停滞和细胞凋亡[1]
MCT1-IN-3(1.0、2.0、3.5 和 5.0 μM)显示可使这些癌细胞对抗肿瘤药物敏感[1]
MCT1-IN-3 还对多药转运蛋白 ABCB1 具有显著的抑制作用,并显示可逆转 ABCB1 介导的多药耐药性 (MDR)[1]

Cell Cycle Analysis[1]

Cell Line:A-549 cells
Concentration:5 μM
Incubation Time:24 h
Result:Caused a disruption of the cell cycle of A-549 cancer cells, indicated by a shift from the predominant Go/G, phase.

Apoptosis Analysis[1]

Cell Line:A-549 cells
Concentration:5 μM
Incubation Time:24 h
Result:Increased the percentage of total apoptotic cells by a factor of 13 from 0.51 to 6.68%.
分子量

389.40

Formula

C22H19N3O4

CAS 号

2878360-80-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.