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Tetrabenazine mesylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tetrabenazine mesylate图片
CAS NO:804-53-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Ro 1-9569 mesylate
产品介绍
Tetrabenazine (Ro 1-9569) mesylate 是一种可逆的囊泡单胺转运蛋白VMAT2位点抑制剂,其Kd值为 1.34 nM,可用于亨廷顿舞蹈病等多动性运动障碍相关疾病研究。
生物活性

Tetrabenazine (Ro 1-9569) mesylate is a reversible inhibitor of the vesicularmonoamine transporterVMAT2with theKdvalue of 1.34 nM. Tetrabenazine mesylate can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease[1][2][3].

体内研究
(In Vivo)

Tetrabenazine mesylate (subcutaneous injection, 1-10 mg/kg, once) can reduce the aggressive behavior in a dose-dependent manner and the levels of neurotransmitter molecules NE, DA and 5-HT in adult male mice[1].
Tetrabenazine mesylate (intraperitoneal injection, 0-2 mg/kg, once) has selective effects on movement which can significantly attenuate morphine-induced hypermobility but oral tremors and stereotyped behaviors in male ICR mice[2].
Tetrabenazine mesylate (intraperitoneal injection, 0.25-2 mg/kg, once a week) increases tremulous jaw movement (TJM) in a dose-dependent manner in adult male Sprague-Dawley rat[3].

Animal Model:Adult male MAO A KO or wide type mice aged 1-2 months[1]
Dosage:1-10 mg/kg
Administration:Subcutaneous injection; once
Result:Completely eliminated the aggressive behavior at a concentration of 5 mg/kg and significantly reduced their NE, DA and 5-HT levels.
Animal Model:Male ICR mice (10 weeks old)[2]
Dosage:0-2 mg/kg
Administration:Intraperitoneal injection; once
Result:Attenuated the subsequent morphine-induced hypermobility after pretreatment with tetrabenazine. Reduced METH-induced increases in locomotion at 1 mg/kg.
Animal Model:Adult male Sprague-Dawley rat weighed 350-450 g[3]
Dosage:0.25-2 mg/kg
Administration:Intraperitoneal injection; once a week
Result:Induced tremulous jaw movement (TJM) significantly at the concentration of 2 mg/kg and more motor impairments with higher doses such as 3-4 mg/kg.
Clinical Trial
分子量

413.53

Formula

C20H31NO6S

CAS 号

804-53-5

中文名称

丁苯那嗪(甲磺酸盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.