Tetrabenazine mesylate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

804-53-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Ro 1-9569 mesylate

产品介绍

Tetrabenazine (Ro 1-9569) mesylate 是一种可逆的囊泡单胺转运蛋白VMAT2位点抑制剂，其K_d值为 1.34 nM，可用于亨廷顿舞蹈病等多动性运动障碍相关疾病研究。

生物活性

Tetrabenazine (Ro 1-9569) mesylate is a reversible inhibitor of the vesicularmonoamine transporterVMAT2with theK_dvalue of 1.34 nM. Tetrabenazine mesylate can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease^[1]^[2]^[3].

体内研究
(In Vivo)

Tetrabenazine mesylate (subcutaneous injection, 1-10 mg/kg, once) can reduce the aggressive behavior in a dose-dependent manner and the levels of neurotransmitter molecules NE, DA and 5-HT in adult male mice^[1].
Tetrabenazine mesylate (intraperitoneal injection, 0-2 mg/kg, once) has selective effects on movement which can significantly attenuate morphine-induced hypermobility but oral tremors and stereotyped behaviors in male ICR mice^[2].
Tetrabenazine mesylate (intraperitoneal injection, 0.25-2 mg/kg, once a week) increases tremulous jaw movement (TJM) in a dose-dependent manner in adult male Sprague-Dawley rat^[3].

Animal Model:	Adult male MAO A KO or wide type mice aged 1-2 months^[1]
Dosage:	1-10 mg/kg
Administration:	Subcutaneous injection; once
Result:	Completely eliminated the aggressive behavior at a concentration of 5 mg/kg and significantly reduced their NE, DA and 5-HT levels.

Animal Model:	Male ICR mice (10 weeks old)^[2]
Dosage:	0-2 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Attenuated the subsequent morphine-induced hypermobility after pretreatment with tetrabenazine. Reduced METH-induced increases in locomotion at 1 mg/kg.

Animal Model:	Adult male Sprague-Dawley rat weighed 350-450 g^[3]
Dosage:	0.25-2 mg/kg
Administration:	Intraperitoneal injection; once a week
Result:	Induced tremulous jaw movement (TJM) significantly at the concentration of 2 mg/kg and more motor impairments with higher doses such as 3-4 mg/kg.

Clinical Trial

分子量

413.53

Formula

C₂₀H₃₁NO₆S

CAS 号

804-53-5

中文名称

丁苯那嗪（甲磺酸盐）

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.