L-Phenylalanine

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L-Phenylalanine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

63-91-2

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
200mg	电议
1 g	电议
5 g	电议
10 g	电议

产品名称

L-苯丙氨酸
(S)-2-Amino-3-phenylpropionic acid

产品介绍

L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine 是一种电压依赖性 α2δ 亚基Ca2⁺通道拮抗剂，K_i为 980 nM。L-Phenylalanine 是NMDARs(K_B573 μM) 和非NMDARs的甘氨酸和谷氨酸结合位点的竞争性拮抗剂。L-Phenylalanine 广泛用于食品香料和药品的生产中。

生物活性

L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated fromEscherichia coli. L-Phenylalanine is aα2δ subunit of voltage-dependent Ca⁺channelsantagonist with aK_iof 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites ofN-methyl-D-aspartate receptors (NMDARs)(K_Bof 573 μM ) andnon-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals^[1]^[2]^[3]^[4].

IC₅₀& Target

NMDA Receptor

Microbial Metabolite

Human Endogenous Metabolite

体外研究
(In Vitro)

DAHP synthetase (DS) and chorismate mutase/prephenate dehydratase (CM/PD) are key enzymes in the L-Phenylalanine biosynthesis pathway. DS is sensitive to feedback inhibition by tyrosine, and CM/PD is subject to feedback inhibition by L-Phenylalanine^[1]. L-Phenylalanine attenuates non-NMDA receptor function in cultured neurons with an IC₅₀of 980 μM^[5].

体内研究
(In Vivo)

The effects of L-Phenylalanine on NMDA-activated currents (I_NMDA) are studied in cultured hippocampal neurons from newborn rats using the patch-clamp technique. L-Phenylalanine specifically and reversibly attenuates I_NMDAin a concentration-dependent manner (IC₅₀of 1.71 mM). L-Phenylalanine inhibits specifically NMDAR current in hippocampal neurons by competing for the glycine-binding site^[3].

Clinical Trial

分子量

165.19

性状

Solid

Formula

C₉H₁₁NO₂

CAS 号

63-91-2

中文名称

L-苯丙氨酸；L-苯基丙氨酸

结构分类

Amino acids

来源

Escherichia coli

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 6.67 mg/mL(40.38 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	6.0536 mL	30.2682 mL	60.5364 mL
5 mM	1.2107 mL	6.0536 mL	12.1073 mL
10 mM	0.6054 mL	3.0268 mL	6.0536 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 9.09 mg/mL (55.03 mM); Clear solution; Need ultrasonic and warming and heat to 60℃

*以上所有助溶剂都可在本网站选购。