CAS NO: | 52-52-8 |
包装 | 价格(元) |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is antagonist ofNMDAreceptor associated glycine receptor, with aKiof 600 μM. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine has anxiolytic and cytostatic effects[1][2][3][4]. | ||||||||||||||||
IC50& Target | Ki: 600 μM (NMDA)[1][2] | ||||||||||||||||
体外研究 (In Vitro) | Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts[5]. | ||||||||||||||||
体内研究 (In Vivo) | Cycloleucine (0.5-4 μg; intracerebroventrical injection) increases time spent in open arms, open arm entries, and extreme arrivals in rats[3].
Cycloleucine reduces thymus and spleen weights inSemliki Forestvirus (SFV) strain A7(74) infected and control mice[6].
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分子量 | 129.16 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C6H11NO2 | ||||||||||||||||
CAS 号 | 52-52-8 | ||||||||||||||||
中文名称 | 环亮氨酸;1氨基环戊烷甲酸 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: H2O : 20 mg/mL(154.85 mM;Need ultrasonic) DMSO :< 1 mg/mL (ultrasonic)(insoluble or slightly soluble) 配制储备液
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以下溶剂前显示的百
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