CNQX (FG9065) is a potent and competitiveAMPA/kainate receptorantagonist withIC₅₀s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitivenon-NMDA receptorantagonist^[1]. CNQX blocks the expression of fear-potentiated startle in rats^[5].

IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)^[1]

CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices^[2].
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments^[3].

CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices^[2].
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments^[3].

232.15

Solid

C₉H₄N₄O₄

115066-14-3

Room temperature in continental US; may vary elsewhere.

DMSO : 20 mg/mL(86.15 mM;Need ultrasonic)

H₂O :< 0.1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble)

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