您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Actinonin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Actinonin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Actinonin图片
CAS NO:13434-13-4
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
Actinonin ((-)-Actinonin) 是一种由放线菌产生的天然抗菌剂。
Cas No.13434-13-4
别名放线酰胺素,(-)-Actinonin,Ro 06-1467
化学名(2R)-N4-hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-butanediamide
Canonical SMILESO=C([C@H](C(C)C)NC([C@H](CCCCC)CC(NO)=O)=O)N1CCC[C@H]1CO
分子式C19H35N3O5
分子量385.5
溶解度30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Actinonin is a peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases. It inhibits the following matrix metalloproteinases (MMPs): MMP-1 (Ki = 300 nM), MMP-3 (Ki = 1,700 nM), MMP-8 (Ki = 130 nM), and MMP-9 (Ki = 330 nM).[1] Actinonin acts as an herbicide by targeting plastid peptide deformylase, an enzyme required for N-terminal processing of plastid-encoded proteins.[2] Actinonin has also been identified as an effective inhibitor of human meprin α (Ki = 20 nM), a zinc endopeptidase that cleaves matrix proteins.[3] More recently actinonin has been shown to inhibit tumor cell invasion and matrix degradation and to induce apoptosis in animal models by targeting human mitochondrial peptide deformylase.[4]

Reference:
[1]. Wahl, R.C., Pulvino, T.A., Mathiowetz, A.M., et al. Hydroxamate inhibitors of human gelatinase B (92 kDa). Bioorganic & Medicinal Chemistry Letters 5(4), 349-352 (1995).
[2]. Duke, S.O., and Dayan, F.E. Modes of action of microbially-produced phytotoxins. Toxins (Basel) 3(8), 1038-1064 (2011).
[3]. Kruse, M.N., Becker, C., Lottaz, D., et al. Human meprin α and β homo-oligomers: Cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochemistry Journal 378(1), 383-389 (2004).
[4]. Lee, M.D., She, Y., Soskis, M.J., et al. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. Journal of Clinical Investigation 114(8), 1107-1116 (2004).