CAS NO: | 90-65-3 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Cas No. | 90-65-3 |
别名 | 青霉酸,NSC 402844 |
化学名 | 3-methoxy-5-methyl-4-oxo-2,5-hexadienoic acid |
Canonical SMILES | C=C(C)C(/C(OC)=C\C(O)=O)=O |
分子式 | C8H10O4 |
分子量 | 170.2 |
溶解度 | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Penicillic acid is synthesized by a large number of fungi, such as P. puberulum, Penicillium stoloniferum, P. eye/opium Penicillium martensii, Penicillium thomii. The synthesis of this secondary metabolite has little or no taxonomic significance [1]. In vitro: The compound was active primarily against gram-negative bacteria, and it was also active against some gram-positive species. It showed limited antihelminthic properties but did affect the growth of oat seed coleoptiles by interference with the respiratory process. Penicillic acid has proven to be too toxic for use in therapy [1]. Penicillic acid (80 μM) inhibited bacterial quorum sensing communication in P. aeruginosa by selectively repressing various virulence factor and other quorum sensing-regulated genes [2]. In Burkitt’s lymphoma Raji cells, penicillic acid exihibited an inhibitory effect on Fas-mediated apoptosis at 100-200 μM by targeting caspase-8 activity [3]. In vivo: The LDso (subcutaneous injection) for mice is 100 mg/kg. Subcutaneous injection of 1.0 mg/dose twice weekly produced transplantable tumors after 64 weeks in all rats surviving treatment. In addition, a dose at 0.1 mg initiated tumor development [1]. References: |