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Penicillic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Penicillic Acid图片
CAS NO:90-65-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
青霉酸是由几种曲霉属和青霉属产生的聚酮化合物霉菌毒素。
Cas No.90-65-3
别名青霉酸,NSC 402844
化学名3-methoxy-5-methyl-4-oxo-2,5-hexadienoic acid
Canonical SMILESC=C(C)C(/C(OC)=C\C(O)=O)=O
分子式C8H10O4
分子量170.2
溶解度≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Penicillic acid is synthesized by a large number of fungi, such as P. puberulum, Penicillium stoloniferum, P. eye/opium Penicillium martensii, Penicillium thomii. The synthesis of this secondary metabolite has little or no taxonomic significance [1].

In vitro: The compound was active primarily against gram-negative bacteria, and it was also active against some gram-positive species. It showed limited antihelminthic properties but did affect the growth of oat seed coleoptiles by interference with the respiratory process. Penicillic acid has proven to be too toxic for use in therapy [1]. Penicillic acid (80 μM) inhibited bacterial quorum sensing communication in P. aeruginosa by selectively repressing various virulence factor and other quorum sensing-regulated genes [2]. In Burkitt’s lymphoma Raji cells, penicillic acid exihibited an inhibitory effect on Fas-mediated apoptosis at 100-200 μM by targeting caspase-8 activity [3].

In vivo: The LDso (subcutaneous injection) for mice is 100 mg/kg. Subcutaneous injection of 1.0 mg/dose twice weekly produced transplantable tumors after 64 weeks in all rats surviving treatment. In addition, a dose at 0.1 mg initiated tumor development [1].

References:
[1] Ciegler A, Detroy R W, Lillehoj E B.  Patulin, penicillic acid, and other carcinogenic lactones[J]. Microbial toxins, 1971, 6: 409-434.
[2] Rasmussen T B, Skindersoe M E, Bjarnsholt T, et al.  Identity and effects of quorum-sensing inhibitors produced by Penicillium species[J]. Microbiology, 2005, 151(5): 1325-1340.
[3] Bando M, Hasegawa M, Tsuboi Y, et al.  The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex[J]. Journal of Biological Chemistry, 2003, 278(8): 5786-5793.