| CAS NO: | 518-75-2 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 518-75-2 |
| 别名 | 桔霉素; NSC 186 |
| 化学名 | (3R,4S)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid |
| Canonical SMILES | O=C1C(C)=C2[C@@H](C)[C@H](C)OC=C2C(O)=C1C(O)=O |
| 分子式 | C13H14O5 |
| 分子量 | 250.3 |
| 溶解度 | ≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Citrinin is a mycotoxin inducing apoptosis and blocking tubulin polymerization and mitotic spindle assembly. Citrinin is a mycotoxin originally isolated from P. citrinum that is also produced by a variety of other fungi that are found as contaminants in human foodstuffs and animal feeds. In vitro: Previous study found that exposure of HEK293 cells to citrinin led to an arrest of cell cycle G2/M in a concentration-dependent increase. Citrinin treatment could also elevate the expression levels of p53 and p21 proteins, yet attenuate the signals of phosphorylated cell division cycle 2. Moreover, treating HEK293 with citrinin could increase both the value of mitotic index and the population of cells, indicating that arrest of citrinin -induced cell cycle occurred mainly during the mitotic phase [1]. In vivo: Previous study showed that citrinin acted as a nephrotoxin in all tested animal species, but its acute toxicity varied in different species. The 50% lethal dose for ducks is 57 mg/kg; for chickens it is 95 mg/kg; and for rabbits it is 134 mg/kg. In murine kidneys, citrinin could also synergistically act with ochratoxin A to depress RNA synthesis [2]. Clinical trial: Up to now, there is no clinical data reported. References: |
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