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Cilobradine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cilobradine hydrochloride图片
CAS NO:186097-54-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品名称
DK-AH 269
产品介绍
Cilobradine是一种HCN通道阻断剂。
生物活性

Cilobradine is anHCN Channelblocker; an open channel blocker of neuronal Ih and related cardiac If channels. Target:HCN Channelblocker Cilobradine is aHCN channelblocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine inhibits WT mHCN2 channel current by 86 ± 2% (n = 5). In contrast, I432A and A425G channel currents were only reduced by 14 ± 1% (n = 4) and 19 ± 2% (n = 8), respectively, by this concentration of Cilobradine. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine (8 ± 2% inhibition; n = 4).

Clinical Trial
分子量

519.07

性状

Solid

Formula

C28H39ClN2O5

CAS 号

186097-54-1

中文名称

西洛雷定盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : ≥ 125 mg/mL(240.82 mM)

H2O : 100 mg/mL(192.65 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.9265 mL9.6326 mL19.2652 mL
5 mM0.3853 mL1.9265 mL3.8530 mL
10 mM0.1927 mL0.9633 mL1.9265 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。