CAS NO: | 17306-46-6 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
20mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Rhoifolin is a flavone glycoside can be isolated fromRhus succedanea. Rhoifolin has anti-diabetic effect acting through enhancedadiponectinsecretion, tyrosine phosphorylation ofinsulinreceptor-βandglucose transporter 4 (GLUT 4)translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-inducedNF-κBandMAPKpathways. Rhoifolin also has cytotoxic activity against differentcancercell lines[1][2][3]. | ||||||||||||||||
IC50& Target[1][2] |
| ||||||||||||||||
体外研究 (In Vitro) | Rhoifolin (0-0.1 μM) has cytotoxic activity against different cancer cell lines with 77.0 nM, 60.1 nM, 39.0 nM, 10.7 nM and 10.1 nM in MRC-5, HCT, HepG2, HeLa and Hep2, respectively[3]. | ||||||||||||||||
体内研究 (In Vivo) | Rhoifolin (12, 24, 30, 36, and 40 mg/kg; PO, for 7 days) has radioprotective effect against radiation-induced decrease of blood platelets and cardiac biochemical lesions in whole body irradiated mice[4].
| ||||||||||||||||
分子量 | 578.52 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C27H30O14 | ||||||||||||||||
CAS 号 | 17306-46-6 | ||||||||||||||||
中文名称 | 野漆树苷 | ||||||||||||||||
结构分类 |
| ||||||||||||||||
来源 |
| ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 62.5 mg/mL(108.03 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
|