CGP52432 is aGABA_Breceptorantagonist, with anIC₅₀of 85 nM.

IC50: 85 nM (GABA_Breceptor)^[1]

CGP52432 is a GABA_Breceptor antagonist, with an IC₅₀of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively^[1].

CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze^[2]. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats^[3].

384.24

Solid

C₁₅H₂₄Cl₂NO₄P

139667-74-6

Room temperature in continental US; may vary elsewhere.

DMSO : 5 mg/mL(13.01 mM;Need ultrasonic and warming)

H₂O : 4 mg/mL(10.41 mM;ultrasonic and warming and heat to 60℃)

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储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。