CAS NO: | 1134-47-0 |
包装 | 价格(元) |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
10 g | 电议 |
50 g | 电议 |
生物活性 | Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropicGABABreceptor (GABABR)agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABABreceptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research[1][2][3]. | ||||||||||||||||
体外研究 (In Vitro) | Baclofen (1, 10 μM; 24 h) causes markedly decreased lactate dehydrogenase (LDH) activity, indicating increased cell viability in wild-type or mutant huntingtin-expressing striatal cells (HD19 or HD43). Baclofen significantly increases chymotrypsin-like proteasome activity and cell viability were in the HD43 cells[3]. | ||||||||||||||||
体内研究 (In Vivo) | Baclofen (i.p.; 10 μg/g; twice daily for 3 consecutive days) ameliorates motor deficits in YAC128 HD transgenic mice[3].
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Clinical Trial | |||||||||||||||||
分子量 | 213.66 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C10H12ClNO2 | ||||||||||||||||
CAS 号 | 1134-47-0 | ||||||||||||||||
中文名称 | 巴氯芬;氯苯氨丁酸 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: H2O : 2 mg/mL(9.36 mM;Need ultrasonic) DMSO :< 1 mg/mL(insoluble or slightly soluble) 配制储备液
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以下溶剂前显示的百
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