DL-TBOA ammonium is a potent non-transportable inhibitor ofexcitatory amino acid transporterswithIC₅₀s of 70 μM, 6 μM and 6 μM forexcitatory amino acid transporter-1 (EAAT1),EAAT2andEAAT3, respectively. DL-TBOA ammonium inhibits the uptake of [¹⁴C]glutamate in COS-1 cells expressing the humanEAAT1andEAAT2withK_ivaluesof 42 μM and 5.7 μM, respectively. DL-TBOA ammonium blocksEAAT4andEAAT5in a competitive manner withK_ivalues of 4.4 μM and 3.2 μM, respectively^[1][2][3].

IC50: 70 μM (EAAT1), 6 μM (EAAT2), 6 μM (EAAT3); Ki: 42 μM (human EAAT1), 5.7 μM (human EAAT2), 4.4 μM (EAAT4), 3.2 μM (EAAT5)^[1][2][3]

DL-TBOA ammonium (70-350 μM; 48 hours) treatment concentration-dependently enhances SN38-induced loss of viability. DL-TBOA reversed Oxaliplatin-induced loss of viability^[4].
DL-TBOA ammonium (350 μM; 24 hours) decreases p53 induction by SN38 and oxaliplatin^[4].

DL-TBOA ammonium (10 nmol; i.c.v.) to morphine-dependent rats significantly facilitates the expression of naloxone-precipitated somatic signs and conditioned place aversion^[5].

256.26

C₁₁H₁₆N₂O₅

2093503-71-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.