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5J-4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5J-4图片
CAS NO:827001-82-1
包装:10mg
市场价:1650元

产品介绍
5J-4 是一种有效的CRAC抑制剂。5J-4 减少了浸润到 CNS 中的单核细胞的数量,并显着减少浸润的 CD4+ 细胞。5J-4 可减轻炎症小鼠模型中 EAE (实验性自身免疫性脑脊髓炎) 的症状并延缓其发作。
生物活性

5J-4 is a potentCRACinhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation[1].

体内研究
(In Vivo)

5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt[1].
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE[1].

Animal Model:C57BL/6 mice (MOG35-55 peptide-immunized mice)[1]
Dosage:2 m/kg
Administration:I.p., every alternate day for 30 days
Result:Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.
分子量

312.34

性状

Powder

Formula

C16H12N2O3S

CAS 号

827001-82-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month