CAS NO: | 1219927-22-6 |
包装: | 5mg |
市场价: | 3500元 |
生物活性 | RO2959 hydrochloride is a potent and selectiveCRAC channelinhibitor with anIC50of 402 nM. RO2959 hydrochloride is a potent blocker ofstore operated calcium entry (SOCE)mediated byOrai1/Stim1 channelswith anIC50of 25 nM. RO2959 hydrochloride is also a potent inhibitor ofhumanIL-2production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways[1][2]. | |||
IC50& Target[1] |
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体外研究 (In Vitro) | RO2959 inhibits Orai1 and Orai3 with IC50values of 25 nM and 530 nM, respectively. RO2959 blocks store operated calcium entry (SOCE) in activated CD4+T lymphocytes with an IC50value of 265 nM[1]. | |||
性状 | Solid | |||
Formula | C21H19F2N5OS.xHCl | |||
CAS 号 | 1219927-22-6 | |||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |