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RO2959 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RO2959 hydrochloride图片
CAS NO:1219927-22-6
包装:5mg
市场价:3500元

产品介绍
RO2959 hydrochloride 是一种有效的选择性CRAC通道抑制剂,IC50为 402 nM。RO2959 hydrochloride 是由Orai1/Stim1通道介导的钙存储进入 (SOCE) 的有效阻滞剂,IC50为 25 nM。RO2959 hydrochloride 还是人IL-2产生的有效抑制剂,有效阻断 T 细胞受体触发的基因表达和 T 细胞功能途径。
生物活性

RO2959 hydrochloride is a potent and selectiveCRAC channelinhibitor with anIC50of 402 nM. RO2959 hydrochloride is a potent blocker ofstore operated calcium entry (SOCE)mediated byOrai1/Stim1 channelswith anIC50of 25 nM. RO2959 hydrochloride is also a potent inhibitor ofhumanIL-2production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways[1][2].

IC50& Target[1]

IL-2

 

CRAC channel

402 nM (IC50)

Orai1/Stim1 channels

25 nM (IC50)

体外研究
(In Vitro)

RO2959 inhibits Orai1 and Orai3 with IC50values of 25 nM and 530 nM, respectively. RO2959 blocks store operated calcium entry (SOCE) in activated CD4+T lymphocytes with an IC50value of 265 nM[1].
RO2959 is a potent SOCE inhibitor that blocks an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+T cells triggered by either T cell receptor (TCR) stimulation or thapsigargin treatment. RO2959 completely inhibits cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction)[1].

性状

Solid

Formula

C21H19F2N5OS.xHCl

CAS 号

1219927-22-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)