CAS NO: | 835904-51-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Synta66 is an inhibitor of store-operated calcium entry channelOrai, which forms the pore of theCRACchannel, and used for the research ofneurological disease. | ||||||||||||||||
IC50& Target | Orai[1] | ||||||||||||||||
体外研究 (In Vitro) | Synta66 is an inhibitor of Orai, which forms the pore of the CRAC channel. Synta66 (10 μM) attenuates peak SOCE in Müller glia. Synta66 (10 μM) prevents orai channels mediating the residual SOC current in Trpc1–/–Müller cells[1]. Synta66 (10 μM) nearly completely blocks the Ca2+entry signal evoked by CaCl2addition, whereas it moderately reduces Ca2+mobilization from stores with 10% to 30% in platelet. Synta66 (10 μM) suppresses human platelet activation in plasma and whole-blood thrombus formation. Synta66 (10 μM) also inhibits murine platelet responses and thrombus formation[2]. Synta66 (10 μM) inhibits LAD2 human mast cell line. Synta66 (10 μM) significantly inhibits FcεRI stimulated histamine and TNFα secretion, and has differential effects on FcεRI stimulated prostaglandin D2 and cytokine release in human lung mast cells (HLMCs)[3]. | ||||||||||||||||
分子量 | 352.36 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H17FN2O3 | ||||||||||||||||
CAS 号 | 835904-51-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 77.5 mg/mL(219.95 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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