您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > CV-159
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CV-159
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CV-159图片
CAS NO:86384-98-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CV-159 是一种二氢吡啶类物质,为Ca2+拮抗剂,同时可抑制钙调蛋白的活性,具有抗炎功效。
生物活性

CV-159 is a unique dihydropyridineCa2+antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities.

体外研究
(In Vitro)

CV-159 (0.1-10 μM) significantly inhibits TNF-α (10 ng/ml, 24 h)-induced VCAM-1 in SMCs in a concentrationdependent manner. CV-159 (10 μM, 30 min) significantly inhibits the TNF-induced ROS production[1]. CV-159 (10 μM) inhibits TNF (24 h)-induced expression of e-selectin but not vascular cell adhesion molecule-1 and intercellular adhesion molecule-1. CV-159 inhibits TNF (20 min)-induced phosphorylation of JNK, p38, and NF-κB p65 (Ser536)[2].

体内研究
(In Vivo)

CV-159 (5 and 10 mg/kg, p.o.) gives significant protection against delayed neuronal death in the hippocampal CA1 region of the rats after 15-min transient forebrain ischemia. CV-159 also diminishes the size of the brain infarct after permanent middle cerebral artery (MCA) occlusion. CV-159 significantly reduces the increase in the water content of the infarcted cortex induced by MCA occlusion[3].

分子量

574.62

Formula

C31H34N4O7

CAS 号

86384-98-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.