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Ganoderic Acid C1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ganoderic Acid C1图片
CAS NO:95311-97-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
灵芝酸 C1,一种可从 G.
Cas No.95311-97-0
别名灵芝酸C1
Canonical SMILESC[C@]12C3=C(C(C[C@@]1([C@]([C@@H](CC(C[C@@H](C)C(O)=O)=O)C)([H])CC2=O)C)=O)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])C[C@@H]3O)C
分子式C30H42O7
分子量514.7
溶解度DMSO: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ganoderic acid C1 is a triterpenoid that has been found inG. lucidumand has diverse biological activities.1,2,3,4It inhibits angiotensin-converting enzyme (ACE; IC50= 745 µM).2Ganoderic acid C1 also inhibits HIV-1 protease with an IC50value of 180 µM.1It reduces the proliferation of murine Lewis lung carcinoma cells but not murine Meth-A sarcoma cells (EC50s = 17 and >20 µg/ml, respectively).3Ganoderic acid C1 (20 µg/ml) inhibits LPS-induced NF-κB phosphorylation and production of TNF-α in RAW 264.7 cells, as well as in peripheral blood mononuclear cells (PBMCs) isolated from patients with asthma.4

1.El-Mekkawy, S., Meselhy, M.R., Nakamura, N., et al.Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidumPhytochemistry49(6)1651-1657(1998) 2.Hai-Bang, T., and Shimizu, K.Structure-activity relationship and inhibition pattern of reishi-derived (Ganoderma lingzhi) triterpenoids against angiotensin-converting enzymePhytochem. Lett.12243-247(2015) 3.Min, B.S., Gao, J.J., Nakamura, N., et al.Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cellsChem. Pharm. Bull. (Tokyo)48(7)1026-1033(2000) 4.Liu, C., Yang, N., Song, Y., et al.Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patientsInt. Immunopharmacol.27(2)224-231(2015)