Flunarizine

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Flunarizine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

52468-60-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Flunarizine 是一种有效的Na⁺/Ca²⁺(T 型) 通道双重阻滞剂。Flunarizine 是D₂多巴胺受体拮抗剂。Flunarizine 具有抗惊厥和抗偏头痛活性，以及外周血管扩张作用。

生物活性

Flunarizine is a potent dualNa⁺/Ca²⁺channel (T-type)blocker. Flunarizine is aD₂dopaminereceptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects^[1]^[2]^[3]^[4]^[5].

IC₅₀& Target^[1]^[2]

D₂Receptor

体外研究
(In Vitro)

Flunarizine blocks sodium currents (I_Na) and calcium currents (I_Ca) with IC₅₀values of 0.94 μM and 1.77 μM in cultured rat cortical neurons, respectively^[2].
Flunarizine (10 and 30 μM; 24 h) shows cytotoxic effects to chromaffin cells^[4].
Flunarizine (1-30 μM) causes clear cytoprotection of chromaffin cell at concentrations of 3-10 μM^[4].

Cell Cytotoxicity Assay^[4]

Cell Line:	Chromaffin cells^[4]
Concentration:	10 and 30 μM
Incubation Time:	24 hours
Result:	Showed a tendency to increase cell death at the concentration of 10 μM, and showed near 100% cell loss at the concentration of 30 μM.

体内研究
(In Vivo)

Flunarizine (intraperitoneal injection; 30 mg/kg; once) protects mice from lipopolysaccharide- (LPS-) induced acute lung injury (ALI)^[5].

Animal Model:	Male BALB/c mice (6-8 weeks old) with acute lung injury induced by lipopolysaccharide^[5]
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection; 30 mg/kg; once
Result:	Suppressed the LPS-induced cell influx, protein leakage, and inflammatory cytokines release. Inhibited the pulmonary inflammation.

Clinical Trial

分子量

404.49

Formula

C₂₆H₂₆F₂N₂

CAS 号

52468-60-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.