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S-8921
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
S-8921图片
CAS NO:151165-96-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
S-8921 是一种回肠 Na+/胆汁酸协同转运蛋白 (IBAT) 的抑制剂。
生物活性

S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor.

IC50& Target

IBAT[1]

体外研究
(In Vitro)

S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor. S-8921 inhibits the uptake velocity of 60 μM [3H] taurocholate dose-dependently in IBAT-COS cells, and the IC50value of S-8921 is 66±8 μM[1].

体内研究
(In Vivo)

Seven-day treatment with S-8921 causes a dramatic decrease of serum cholesterol concentrations in hamsters. The hypocholesterolemic effects of S-8921 are dose-dependent, but S-8921 does not affect body weight. An increase of fecal bile acid excretion is observed especially at higher doses of S-8921[1]. S-8921 treatment for 1 to 2 weeks causes a decrease in serum total cholesterol concentrations, with 0.01% S-8921 (4.0 to 4.6 mg/kg) being almost maximally effective[2].

分子量

540.60

Formula

C30H36O9

CAS 号

151165-96-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.