CAS NO: | 1269440-17-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Encorafenib (LGX818) is a highly potentBRAFinhibitor with selective anti-proliferative and apoptotic activity in cells expressingBRAFV600E(EC50=4 nM). | ||||||||||||||||
IC50& Target | IC50: 0.3 nM (BRafV600E) | ||||||||||||||||
体外研究 (In Vitro) | Encorafenib (LGX818) is a potent drug that can prevents diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf[1]. Encorafenib (LGX818) (10 nM) suppresses the ERK/MAPK pathway and displays marked inhibition of pERK in A375, G361 and SK-MEL-24 cells. 10 nM Encorafenib (LGX818) treatment for 12 days potently inhibits colony formation in A375, G361 and SK-MEL-24 cells, but not in RPMI7951 and C8161 cells. Encorafenib (LGX818) treatment induces a steady increase in the β-catenin level in G361 cells over time[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 540.01 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C22H27ClFN7O4S | ||||||||||||||||
CAS 号 | 1269440-17-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(92.59 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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