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Atraric acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Atraric acid图片
CAS NO:4707-47-5
包装与价格:
包装价格(元)
100mg电议
500mg电议
1 g电议
5 g电议
10 g电议

产品名称
Methyl atrarate
产品介绍
Atraric acid (Methyl atrarate) 是一种特异的雄激素受体 (androgen receptor) 拮抗剂,具有抗炎和抗癌作用。Atraric acid 抑制 LNCaP 和 C4-2 细胞中内源性前列腺特异性抗原基因的表达。Atraric acid 还能抑制NO和细胞因子的合成,抑制MAPK-NFκB信号通路。Atraric acid 可用于前列腺疾病和炎症性疾病的研究。
生物活性

Atraric acid (Methyl atrarate) is a specificandrogen receptor(AR)antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis ofNOand cytokine, and suppress theMAPK-NFκBsignaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases[1][2].

IC50& Target

Androgen receptor, NO synthesis, MAPK-NFκB pathway[1][2]

体外研究
(In Vitro)

Atraric acid (10 μM; CV1 cells) represses the transactivation function mediated by Dihydrotestosterone-induced human AR[1].
Atraric acid (10 μM; PCa cells) inhibits the expression of the PSA gene in both androgen-dependent and androgen-independent PCa cells[1].
Atraric acid (1-300 μM; 24 h) dose-dependently inhibits pro-inflammatory cytokine, nitric oxide, prostaglandin E2 in LPS-stimulated RAW264.7 cells, but does not influence the cell viability[2].
Atraric acid (100 and 300 μM; 18 h or 4 h) downregulates the expression of phosphorylated IκB, extracellular signal-regulated kinases (ERK) and nuclear factor kappa B (NFκB) signaling pathway to exhibit anti-inflammatory effects in LPS-stimulated RAW264.7 cells[2].

Cell Viability Assay[2]

Cell Line:RAW264.7 cells
Concentration:1-300 μM
Incubation Time:24 h
Result:Did not influence the cell viability.

Western Blot Analysis[2]

Cell Line:RAW264.7 cells
Concentration:100 and 300 μM
Incubation Time:18 h or 4 h
Result:Inhibited LPS-Induced expression of iNOS and COX-2 in a dose-dependent manner.
Suppressed LPS-stimulated phosphorylation of the Nfκb signaling pathway.
体内研究
(In Vivo)

Atraric acid (10, 30 mg/kg; i.p.; single dosage) inhibits the production of pro-inflammatory cytokines and reduces pathological damages in LPS-induced endotoxin shock mice[2].

Animal Model:Female BALB/c mice (7 weeks old, 17-20 g; LPS-induced endotoxin shock)[2]
Dosage:10, 30 mg/kg
Administration:i.p.; single dosage
Result:Inhibited the production of pro-inflammatory cytokines.
Reduced pathological damages such as vasodilation and bleeding.
分子量

196.20

性状

Solid

Formula

C10H12O4

CAS 号

4707-47-5

结构分类
  • Phenols
来源
  • Plants
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)