K783-0308

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K783-0308

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

422554-29-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

K783-0308 是一种有效且选择性的FLT3和MNK2双重抑制剂，IC₅₀值分别为 680 和 406 nM。 K783-0308 抑制 MOLM-13 (IC₅₀=10.5 μM) 和 MV-4-11 (IC₅₀=10.4 μM) 细胞的生长。K783-0308 促进急性髓性白血病 (AML) 细胞的凋亡 (apoptosis) 并使细胞周期停滞在 G0/G1 期。

生物活性

K783-0308 is a potent and selective dual inhibitor ofFLT3andMNK2withIC₅₀values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC₅₀=10.5 μM) and MV-4-11 (IC₅₀=10.4 μM) cells. K783-0308 promotes acute myeloid leukemia (AML) cellapoptosisand cell cycle arrests in the G0/G1 phase^[1].

IC₅₀& Target

MNK2

406 nM (IC₅₀)

体外研究
(In Vitro)

K783-0308 (MOLM-13, MV-4-11 cells) shows cytotoxic effect against MOLM-13 (IC₅₀=10.5 μM) and MV-4-11 (IC₅₀=10.4 μM) cells^[1].
K783-0308 (1, 3, 10, 30 μM) promotes AML cell apoptosis and cell cycle arrests in the G0/G1 phase^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	MOLM-13, MV-4-11 cells (RPMI-1640 supplemented with streptomycin (100 μg/mL)/penicillin (100 U/mL)/ amphotericin B (0.25 μg/mL))
Concentration:	1, 3, 10, 30 μM
Incubation Time:	48 h, 72 h
Result:	Promotes AML cell apoptosis and cell cycle arrested in the G0/G1 phase.

分子量

333.43

Formula

C₂₁H₂₃N₃O

CAS 号

422554-29-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.