MNK1/2-IN-6

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MNK1/2-IN-6

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

MNK1/2-IN-6 是一种有效的选择性的MNK1/2抑制剂，IC₅₀s 分别为 2.3 nM 和 3.4 nM。 MNK1/2-IN-6 以浓度依赖性方式诱导细胞凋亡apoptosis。

生物活性

MNK1/2-IN-6 is a potent and selectiveMNK1/2inhibitor withIC₅₀s of 2.3 nM and 3.4 nM forMNK1andMNK2, respectively. MNK1/2-IN-6 inducesapoptosisin a concentration-dependent manner^[1].

IC₅₀& Target^[1]

MNK1

2.3 nM (IC₅₀)

MNK2

3.4 nM (IC₅₀)

体外研究
(In Vitro)

MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC₅₀s of 0.3896μM, 0.4092 μM for TMD-8, DOHH-2 cells, respectively^[1].
MNK1/2-IN-6 (0.25, 0.5, 1 μM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner^[1].

Cell Proliferation Assay^[1]

Cell Line:	TMD-8, DOHH-2 cells
Concentration:
Incubation Time:	72 h
Result:	Showed antiproliferative activity with IC₅₀s of 0.39μM, 0.41 μM for TMD-8, DOHH-2 cells, respectively.

Apoptosis Analysis^[1]

Cell Line:	TMD-8 cells
Concentration:	0.25, 0.5, 1 μM
Incubation Time:	24 h
Result:	Induced TMD-8 cells apoptosis in a concentration-dependent manner.

分子量

448.52

Formula

C₂₇H₂₄N₆O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.