CAS NO: | 1199590-75-4 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | GNE-220 is a potent and selective inhibitor ofMAP4K4with anIC50of 7 nM. | |||
IC50& Target |
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体外研究 (In Vitro) | GNE-220 also inhibits a few other kinases with IC50s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM+retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1+long focal adhesions (FAs)[1]. | |||
分子量 | 438.53 | |||
Formula | C25H26N8 | |||
CAS 号 | 1199590-75-4 | |||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |