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GNE 220
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GNE 220图片
CAS NO:1199590-75-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
GNE-220 是一种有效的选择性MAP4K4抑制剂,IC50为 7 nM。
生物活性

GNE-220 is a potent and selective inhibitor ofMAP4K4with anIC50of 7 nM.

IC50& Target

MAP4K4

7 nM (IC50)

MAP4K5

9 nM (IC50)

MAP4K6

1.1 μM (IC50)

体外研究
(In Vitro)

GNE-220 also inhibits a few other kinases with IC50s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM+retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1+long focal adhesions (FAs)[1].

分子量

438.53

Formula

C25H26N8

CAS 号

1199590-75-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.