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MAP4K4-IN-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MAP4K4-IN-3图片
CAS NO:1811510-58-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
MAP4K4-IN-3 (Compound 17) 是一种有效的选择性MAP4K4抑制剂,在激酶实验中IC50为 14.9 nM,在细胞实验中IC50为 470 nM。具有抗糖尿病活性。
生物活性

MAP4K4-IN-3 (Compound 17) is a potent and selectiveMAP4K4inhibitor with anIC50of 14.9 nM in kinase assay, anIC50of 470 nM in cell assay. Antidiabetic agent[1].

IC50& Target

MAP4K4

14.9 nM (IC50)

体外研究
(In Vitro)

MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic agents[1].

体内研究
(In Vivo)

Oral dosing in telemetered rats for 5 days with MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) results in a number of adverse effects. Substantial weight losses (7%) and body temperature increases (0.4℃) relative to controls are observed over the course of the study. For cardiovascular end points, maximal heart rate increases of 25 bpm, relative to controls, are induced by treatment with MAP4K4-IN-3[2].

分子量

297.74

性状

Solid

Formula

C15H12ClN5

CAS 号

1811510-58-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 10 mg/mL(33.59 mM;ultrasonic and warming and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.3586 mL16.7932 mL33.5864 mL
5 mM0.6717 mL3.3586 mL6.7173 mL
10 mM0.3359 mL1.6793 mL3.3586 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。