CAS NO: | 1811510-58-3 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | MAP4K4-IN-3 (Compound 17) is a potent and selectiveMAP4K4inhibitor with anIC50of 14.9 nM in kinase assay, anIC50of 470 nM in cell assay. Antidiabetic agent[1]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic agents[1]. | ||||||||||||||||
体内研究 (In Vivo) | Oral dosing in telemetered rats for 5 days with MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) results in a number of adverse effects. Substantial weight losses (7%) and body temperature increases (0.4℃) relative to controls are observed over the course of the study. For cardiovascular end points, maximal heart rate increases of 25 bpm, relative to controls, are induced by treatment with MAP4K4-IN-3[2]. | ||||||||||||||||
分子量 | 297.74 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C15H12ClN5 | ||||||||||||||||
CAS 号 | 1811510-58-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 10 mg/mL(33.59 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |