CAS NO: | 2448286-21-1 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | GNE 220 (hydrochloride) is a potent and selective inhibitor ofMAP4K4, with anIC50of 7 nM. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | GNE-220 also inhibits a few other kinases with IC50s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM+retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1+long focal adhesions (FAs)[1]. | ||||||||||||||||
分子量 | 474.99 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H27ClN8 | ||||||||||||||||
CAS 号 | 2448286-21-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 5.4 mg/mL(11.37 mM;Need ultrasonic) H2O : 5 mg/mL(10.53 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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