CAS NO: | 2680616-96-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | GNE-1858 is a potent and ATP-competitivehematopoietic progenitor kinase-1 (HPK1)inhibitor, withIC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively[1]. | ||||||||||||||||
体外研究 (In Vitro) | Hematopoietic progenitor kinase-1 (HPK1), a serine/threonine Ste20-related protein kinase whose expression is restricted to the hematopoietic compartment (e.g., T cells, B cells, and dendritic cells), is one such kinase. HPK1 is a negative-feedback regulator of T cell receptor signaling, which dampens T cell proliferation and effector function[1]. | ||||||||||||||||
分子量 | 428.48 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H26F2N8 | ||||||||||||||||
CAS 号 | 2680616-96-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 20 mg/mL(46.68 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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