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7,3',4'-Trihydroxyisoflavone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
7,3',4'-Trihydroxyisoflavone图片
CAS NO:485-63-2
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
7,3',4'-Trihydroxyisoflavone 是黄豆苷元的主要代谢物,是Cot (Tpl2/MAP3K8)MKK4的 ATP 竞争性抑制剂。7,3',4'-Trihydroxyisoflavone 具有抗癌、抗血管生成、化学保护和自由基清除活性。
生物活性

7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor ofCot (Tpl2/MAP3K8)andMKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[1][2].

体外研究
(In Vitro)

7,3',4'-Trihydroxyisoflavone triggers cell cycle arrest at the G1 phase and displays an anti-proliferative effect against EGF receptor-positive skin cancer[1].
7,3',4'-Trihydroxyisoflavone also significantly inhibits UVB-induced COX-2 expression by suppressing the NF-B transcription activity in mouse skin epidermal JB6 P+cells[1].

体内研究
(In Vivo)

In a mouse skin tumorigenesis model, 7,3',4'-Trihydroxyisoflavone strongly suppresses the incidence, multiplicity, and volume of UVB-induced mouse skin tumors. Consistent with the tumor data, 7,3',4'-Trihydroxyisoflavone clearly attenuates UVB-induced COX-2 expression in hairless mouse skin[2].

分子量

270.24

性状

Solid

Formula

C15H10O5

CAS 号

485-63-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : ≥ 125 mg/mL(462.55 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.7004 mL18.5021 mL37.0041 mL
5 mM0.7401 mL3.7004 mL7.4008 mL
10 mM0.3700 mL1.8502 mL3.7004 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。