CAS NO: | 2673364-10-6 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | DDO3711, a PP5-recruitingphosphataserecruitment chimeras (PHORCs), is formed by connecting a small molecularapoptosissignal-regulated kinase 1 (ASK1) inhibitor to a PP5 activator through a chemical linker. DDO3711 specifically inhibits ASK1 (IC50=164.1 nM) not ASK2 (IC50>20 μM). DDO3711 significantly dephosphorylates p-ASK1T838by recruiting PP5 and shows the ASK1-dependent antiproliferative activity. DDO3711 has anti-cancer activity and has the potential for abnormally phosphorylated oncoproteins research[1]. | ||||||||||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | DDO3711 (15 μM; 24小时) 通过以 PP5 依赖性方式减少 p-ASK1T838,从而对胃癌细胞显示出抗增殖作用。DDO3711 不抑制 GES-1 细胞和 HGC-27 细胞的增殖[1]。 Cell Proliferation Assay[1]
Cell Cycle Analysis[1]
Western Blot Analysis[1]
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体内研究 (In Vivo) | DDO3711 (20, 40 mg/kg; 腹腔给药; 每天; 持续 21 天)以剂量依赖性方式显着抑制肿瘤生长[1]。
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分子量 | 767.83 | ||||||||||||||||||||||||
Formula | C42H41N9O6 | ||||||||||||||||||||||||
CAS 号 | 2673364-10-6 | ||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |