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CID 5951923
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CID 5951923图片
CAS NO:749872-43-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CID 5951923是一种有效的Krüppel-like factor 5 (KLF5)抑制剂,IC50值为 603 nM,CID 5951923 可在体外抑制癌细胞的增殖。
生物活性

CID 5951923 is a potent inhibitor ofKrüppel-like factor 5 (KLF5), with anIC50of 603 nM. CID 5951923 can inhibit proliferation ofcancercells in vitro[1].

IC50& Target

IC50: 603 nM (KLF5)[1]

体外研究
(In Vitro)

CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner[1].
CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY1068, and downregulated EGR1[1].
CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells[1].

Cell Viability Assay[1]

Cell Line:DLD-1 and IEC-6 cells
Concentration:0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time:48 h
Result:Inhibited proliferation of DLD-1 cells with an IC50of 1.6 μM.
分子量

382.39

Formula

C16H18N2O7S

CAS 号

749872-43-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.