CAS NO: | 169148-63-4 |
包装 | 价格(元) |
100U | 电议 |
300U | 电议 |
生物活性 | InsulinDetemir is an artificialinsulin, shows effect on controlling blood sugar levels.InsulinDetemir stimulatesGLP-1secretion as a consequence of enhanced Gcg expression by a mechanism involving activation ofAkt- and/or extracellular signal-regulated kinase (ERK)-dependent-cat and CREB signaling pathways.InsulinDetemir can be used for type 2 diabetes research[1][2]. | ||||||||||||
体外研究 (In Vitro) | Insulin Detemir (d-INS) (100 nM; 0.5-4 h) increases Gcg mRNA expression in primary fetal rat intestinal cell (FRIC) cultures, and (100 nM; 5 min and 10 min) induces rapid phosphorylation of Akt, as well[1]. Western Blot Analysis[1]
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体内研究 (In Vivo) | Insulin Detemir (d-INS) (5 IU/kg; i.p.; once daily; 2 weeks) demonstrates weight-sparing effects compared with other insulin formulations, and shows a intestinal tissues preference, potentially involving the activation of insulin/-catenin/CREB signaling pathways[1].
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Clinical Trial | |||||||||||||
性状 | Liquid | ||||||||||||
Formula | C267H402N64O76S6 | ||||||||||||
CAS 号 | 169148-63-4 | ||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
储存方式 |
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