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TCS PIM-1 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TCS PIM-1 1图片
CAS NO:491871-58-0
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
10mg电议
50mg电议
100mg电议
200mg电议

产品名称
SC 204330
产品介绍
TCS PIM-1 1 (SC 204330) 是一种有效的,具有选择性和 ATP 竞争性的Pim-1激酶抑制剂,IC50为 50 nM,对 Pim-2 和 MEK1/MEK2 表现出良好的选择性 (IC50>20000 nM)。
生物活性

TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitivePim-1kianse inhibitor with anIC50of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s >20000 nM)[1].

IC50& Target[1]

PIM1

50 nM (IC50)

体外研究
(In Vitro)

TCS PIM-1 1 (compound 1), a substituted pyridone scaffold, binds convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggests that TCS PIM-1 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2. Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors. TCS PIM-1 1 serves both as a starting point for SAR chemical syntheses and was used for co-crystallization with Pim-1 protein[1].

分子量

367.20

性状

Solid

Formula

C18H11BrN2O2

CAS 号

491871-58-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL(272.33 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.7233 mL13.6166 mL27.2331 mL
5 mM0.5447 mL2.7233 mL5.4466 mL
10 mM0.2723 mL1.3617 mL2.7233 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:
  • 1.

    TCS PIM-1 1 is dissolved in 0.5% DMSO[2].