包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | HTH-01-091 TFA is a potent and selectivematernal embryonic leucine zipper kinase (MELK)inhibitor, with anIC50of 10.5 nM. HTH-01-091 TFA also inhibitsPIM1/2/3,RIPK2,DYRK3,smMLCKandCLK2. HTH-01-091 TFA can be uesd for breastcancerresearch[1]. | ||||||||||||||||
IC50& Target | IC50: 10.5 nM (MELK), 41.8 nM (DYRK3), 42.5 nM (RIPK2), 60.6 nM (PIM1), 108.6 nM (smMLCK), 632 nM (mTOR), 962 nM (PIK3CA), 1230 nM (CDK7), 1740 nM (GSK3A)[1] | ||||||||||||||||
体外研究 (In Vitro) | HTH-01-091 (1 μM) TFA 选择性抑制 4% 的激酶超过 90%[1]。 Cell Proliferation Assay[1]
Western Blot Analysis[1]
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分子量 | 613.46 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C28H29Cl2F3N4O4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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