CAS NO: | 1204144-28-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
生物活性 | AZD1208 is an orally bioavailable, highly selectivePIMkinases inhibitor[1]. | ||||||||||||||||
体外研究 (In Vitro) | AZD1208 shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI50values less than 100 nM[1]. AZD1208 (10 μM) inhibits the growth of Ramos cells, and at 1 μM, strongly inhibits PIM kinases in all cell at 1 μM. AZD1208 induces apoptosis, and PIM2 knockdown is mainly associated with an alteration of the cell cycle[2]. The combination of AZD1208 and AZD2014 rapidly activates AMPKα, a negative regulator of translation machinery through mTORC1/2 signaling in AML cells; profoundly inhibits AKT and 4EBP1 activation; and suppresses polysome formation[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 379.48 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H21N3O2S | ||||||||||||||||
CAS 号 | 1204144-28-4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(131.76 mM;Need ultrasonic) 配制储备液
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