CAS NO: | 68844-77-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is ahistamine H1-receptorantagonist, with anIC50of 4 nM. Astemizole also shows potent hERG K+channel blocking activity with an IC50of 0.9 nM. Astemizole has antipruritic effects[1][2]. | ||||||||||||||||
体内研究 (In Vivo) | Astemizole (p.o., 10 and 30 mg/kg) and (i.v., 1 and 3 mg/kg) has no effect on respiratory rate, heart rate and blood pressure, and even at high doses of 30 mg/kg and 3 mg/kg, also has no effect on body temperature and exercise capacity in male common marmosets. But Astemizole can prolong the QT interval and induce premature ventricular contractions at 30 mg/kg (po) and 1 mg/kg (iv)[3]. | ||||||||||||||||
分子量 | 458.57 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C28H31FN4O | ||||||||||||||||
CAS 号 | 68844-77-9 | ||||||||||||||||
中文名称 | 阿司咪唑 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 125 mg/mL(272.59 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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