CAS NO: | 83919-23-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo[1] | ||||||||||||||||
IC50& Target | IC50: Glucocorticoid Receptor | ||||||||||||||||
体外研究 (In Vitro) | Mometasone furoate binds to a glucocorticoid receptor causes conformational changes in the receptor, separation from chaperones, and the receptor moves to the nucleus[1].Mometasone furoate (0.1-10 μM; 2h before LPS stimulation) strongly inhibits LPS-stimulated nitrite production in a concentration-dependent manner in J774 macrophages, The IC50 value is 0.00024 μM for Mometasone furoate in J774 cells[1].Mometasone furoate (0.1-10 μM; 2h before LPS stimulation) is more potent than DEX, it significantly inhibits iNOS expression at a 0.01 μM concentration whereas Dex became active at 0.1 μM. Additionally, the inhibition of cox-2 protein expression at 0.01 μM is 79% for Mometasone furoate and 39% for Dex[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 521.43 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C27H30Cl2O6 | ||||||||||||||||
CAS 号 | 83919-23-7 | ||||||||||||||||
中文名称 | 糠酸莫米松;艾洛松;莫米松糠酸酯;糠酸莫美他松 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(95.89 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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