Methylprednisolone acetate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

53-36-1

包装与价格：

包装	价格(元)
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

泼尼松龙EP杂质

产品介绍

Methylprednisolone acetate，泼尼松龙衍生物，是一种皮质类固醇激素 (corticosteroid hormone)。Methylprednisolone acetate 可以缓解关节炎和其他关节紊乱引起的疼痛和肿胀。

生物活性

Methylprednisolone acetate, a prednisolone derivative, is acorticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disordersin vivo^[1]^[2].

体内研究
(In Vivo)

Methylprednisolone acetate (30 mg/kg, intramuscular injection; additional oral doses of 13 mg/kg for 10 consecutive days）combines with LPS induces typical features of early AVN of the femoral head^[2].

Animal Model:	A mouse model of osteonecrotic femoral head induced by methylprednisolone and liposaccharide^[2]
Dosage:	30 mg/kg; 13 mg/kg for 10 consecutive days
Administration:	30 mg/kg, intramuscular injection; additional oral doses of 13 mg/kg for 10 consecutive days
Result:	Lead to chondrocyte degeneration and fibrocartilage expression after 7 weeks. Increased the density of CD31 and VEGF-R2 markers in the femoral head.

Clinical Trial

分子量

416.51

性状

Solid

Formula

C₂₄H₃₂O₆

CAS 号

53-36-1

中文名称

泼尼松龙EP杂质

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL(240.09 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.4009 mL	12.0045 mL	24.0090 mL
5 mM	0.4802 mL	2.4009 mL	4.8018 mL
10 mM	0.2401 mL	1.2005 mL	2.4009 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。