Leukadherin-1

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Leukadherin-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

344897-95-6

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议
1 g	电议

产品介绍

Leukadherin-1 是特异性的白细胞表面整合素CD11b/CD18的激动剂。Leukadherin-1 可增加 CD11b/CD18 依赖性细胞对血纤蛋白原的粘附，EC₅₀为 4 μM。Leukadherin-1 增强白细胞对配体 (如 ICAM-1) 和血管内皮的粘附，从而减少白细胞跨内皮迁移和流入损伤部位。Leukadherin-1 抑制先天性炎症信号转导。

生物活性

Leukadherin-1, a specific agonist of the leukocyte surfaceintegrinCD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC₅₀of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling^[1]^[2]^[3].

体外研究
(In Vitro)

Leukadherin-1 is a specific agonist of the leukocyte surface integrin CD11b/CD18 (αMβ2; CR3; Mac-1). Leukadherin‐1 pretreatment reduces secretion of interferon (IFN)‐γ, tumour necrosis factor (TNF) and macrophage inflammatory protein (MIP)‐1β by monokine‐stimulated NK cells. Leukadherin‐1 pretreatment also reduces secretion of IL‐1β, IL‐6 and TNF by Toll‐like receptor (TLR)‐2 and TLR‐7/8‐stimulated monocytes^[3].

体内研究
(In Vivo)

Leukadherin-1 (1 mg/kg; i.p.; twice daily for 14 days) is beneficial in preventing hyperoxia-induced neonatal lung injury, an experimental model of bronchopulmonary dysplasia (BPD)^[1].

Animal Model:	Newborn Sprague Dawley rat pups^[1]
Dosage:	1 mg/kg
Administration:	I.p.; twice daily for 14 days
Result:	Beneficial on preventing the lung inflammatory response, improved alveolarization and vascular development, and reduced pulmonary vascular remodeling and PH in a hyperoxia-induced experimental model of BPD.

分子量

421.49

性状

Solid

Formula

C₂₂H₁₅NO₄S₂

CAS 号

344897-95-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 5 mg/mL(11.86 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.3725 mL	11.8627 mL	23.7254 mL
5 mM	0.4745 mL	2.3725 mL	4.7451 mL
10 mM	0.2373 mL	1.1863 mL	2.3725 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。